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CONTRIBUTOR(S): Vetstream Ltd, Gigi Davidson,

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Medication: Amoxicillin-clavulanate

Medication: Amoxicillin-clavulanate

Your dog has been prescribed Amoxicillin-clavulanate for the treatment of a bacterial infection. This medication is often used to treat skin infections, dental infections, urinary tract infections, respiratory infections and enteritis (infections of the intestine associated with diarrhoea).

Key points:
• Antibiotic.
• Dosage: twice daily.
• Should not be handled by people with allergies to penicillins or cephalosporins.

This information sheet is designed to help answer commonly asked questions and help you give the medication safely and effectively to your pet. It does not contain all available information for this medication. If you have other questions or need more information, contact your vet or pharmacist.Always follow the dosing instructions provided by your vet.

Name, Brand names, Class of medication and Storage

Human dosage forms contain varying amounts of clavulanic acid and are not interchangeable with veterinary dosage forms. Veterinary-labelled dosage forms contain amoxicillin and clavulanate in a fixed ratio of 4:1, respectively, and are often labelled for strength as the combination.

Name

  • Amoxicillin-clavulanate (A- mox-i-sih-lin – clav-yoo-la-nayt) or Amoxicillin-Clavulanic Acid.

Brand name

  • Cladaxxa 200mg/50mg Chewable tablets for cats and dogs (UK).
  • Cladaxxa 40mg/10mg Chewable tablets for cats and dogs (UK).
  • Cladaxxa 400mg/100mg Chewable tablets for dogs (UK).
  • Clamoxyl Palatable Tablets 200mg (UK).
  • Clamoxyl Palatable Tablets 40mg (UK).
  • Clavaseptin 250mg Palatable tablets for dogs (UK).
  • Clavaseptin 50mg Palatable tablets for dogs and cats (UK).
  • Clavaseptin 500mg Palatable tablets for dogs (UK).
  • Clavaseptin 62.5mg Palatable tablets for dogs and cats (UK).
  • Clavaseptin 750mg Palatable tablets for dogs (UK).
  • Clavubactin 250/62.5mg Tablets for dogs (UK).
  • Clavubactin 50/12.5mg Tablets for cats and dogs (UK).
  • Clavubactin 500/125mg Tablets for dogs (UK).
  • Clavucil 200mg/50mg Tablets for dogs (UK).
  • Clavucil 40mg/10mg Tablets for dogs and cats (UK).
  • Clavucil 400mg/100mg Tablets for dogs (UK).
  • Clavudale 200mg/50mg Tablets for dogs (UK).
  • Clavudale 40mg/10mg Tablets for dogs and cats (UK).
  • Clavudale 400mg/100mg Tablets for dogs (UK).
  • Kesium 200mg/50mg Chewable Tablets for dogs (UK).
  • Kesium 40mg/10mg Chewable Tablets for cats and dogs (UK).
  • Kesium 400mg/100mg Chewable Tablets for dogs (UK).
  • Kesium 50mg/12.5mg Chewable Tablets for cats and dogs (UK).
  • Kesium 500mg/125mg Chewable Tablets for dogs (UK).
  • Noroclav 250mg Tablets for dogs (UK).
  • Noroclav 50mg Tablets for dogs and cats (UK).
  • Noroclav 500mg Palatable Tablets for dogs (UK).
  • Synuclav 250mg Tablets for dogs (UK).
  • Synuclav 50mg Tablets for dogs and cats (UK).
  • Synuclav Palatable Tablets 500mg for dogs (UK).
  • Synulox Palatable Drops, Powder for Oral Suspension (UK).
  • Synulox Palatable Tablets 250mg (UK).
  • Synulox Palatable Tablets 50mg (UK).
  • Synulox Palatable Tablets 500mg (UK).
  • Clavamox® Chewable Tablets 62.5mg (US).
  • Clavamox® Chewable Tablets 125mg (US).
  • Clavamox® Chewable Tablets 250mg (US).
  • Clavamox® Chewable Tablets 375mg (US).
  • Clavamox® Drops 62.5mg/ml (US).
  • Clavacillin® 62.5mg Tablets for dogs and cats (US).
  • Clavacillin® 125mg Tablets for dogs (US).
  • Clavacillin® 250mg Tablets for dogs (US).
  • Clavacillin® 375mg Tablets for dogs (US).
  • Clamoxy-VetTM Tablets (US).

Class of medication

  • Broad spectrum antimicrobial.

Storage

  • Store at 20°C to 25°C (68°F to 77°F).
  • Oral liquids must be stored in the refrigerator and are stable for 10 days after mixed.

Why has my dog been prescribed Amoxicillin-clavulanate?

Your vet has prescribed Amoxicillin-clavulanate for the treatment of infections caused by one or more of the following bacteria:

  • Staphylococcus aureus.
  • β-lactamase producing Staphylococcus aureus. 
  • Staphylococcus epidermidis. 
  • Staphylococcus intermedius. 
  • Streptococcus faecalis. 
  • Streptococcus species. 
  • Corynebacterium pyogenes.
  • Corynebacterium species. 
  • Erysipelothrix rhusiopathiae. 
  • Bordetella bronchiseptica. 
  • Escherichia coli. 
  • Proteus mirabilis.
  • Proteus species. 
  • Enterobacter species. 
  • Klebsiella pneumoniae. 
  • Salmonella Dublin. 
  • Salmonella typhimurium. 
  • Pasteurella multocida. 
  • Pasteurella haemolytica. 
  • Pasteurella species.

How is the medication given?

Amoxicillin-clavulanate is given orally (as tablets or in liquid form). It is administered twice daily. Tablets and liquid can either be administered directly into your dog’s mouth or along with some food. The liquid should be well-shaken before withdrawing a dose from the bottle.

Many amoxicillin-clavulanate tablets and liquids are very palatable, so be sure to keep them out of your dog's reach.

Are there any side-effects or drug interactions?

Very rarely, hypersensitivity reactions (allergic reactions) may occur. If this happens, stop the treatment and contact your vet immediately.

Amoxicillin-clavulanate should not be used in animals that have previously had an allergic reaction to any penicillin or cephalosporin antibiotics.

Some amoxicillin and clavulanic acid preparations are marketed as being suitable for use in pregnant and lactating animals.

This medication should be used cautiously in animals with liver or kidney disease.

Anorexia (reduced appetite), lethargy (tiredness), vomiting and diarrohea are possible side-effects of amoxicillin-clavulanate and should be reported to your veterinary surgeon. Your pet may be able to continue with the drug, if side effects are mild, but it’s best to let your vet know as soon as possible, so that they can decide whether additional medications or different medications are required.

How long will my dog need to receive this medication?

Amoxicillin-clavulanate tablets or liquids should be administered according to your vet’s instructions. The treatment course usually extends for 5-7 days, or for 48 hours after the resolution of clinical signs. If no improvement is seen within 5 days, your vet may recommend a different course of therapy.

Urinary tract infections and chronic skin infections may require extended courses of treatment of up to 30 days.

How should I dispose of this medication if I don’t use it all?

Dispose of any unused Amoxicillin-clavulanate safely – do not flush down the toilet or sink. Ask your veterinary team if they take back medication for disposal. Do not save Amoxicillin-clavulanate for future use or give to other pets. 

What if I miss a dose or give an extra dose?

If you miss a dose, give the dose as soon as possible but do not give a double dose. Make sure the dose given does not exceed the total recommended dose in any 24-hour period.

My dog is unwell, should I still give the drug?

If your pet is unwell, contact your vet for advice. 

What should I do if this medication is accidentally given to another pet or taken by a human?

Amoxicillin-clavulanate should only be given to the dog that it has been prescribed for. If accidentally given to other pets, contact your vet for advice.

This medication in contraindicated for use in rabbits, guinea-pigs, rats, mice, hamsters and gerbils and may cause a fatal diarrhea in these species. Contact your vet for advice if one of these species accidentally consumes this medication.

If accidentally consumed by a human, speak to your primary care doctor or poison control centre. Amoxicillin-clavulanate can cause allergic reactions in humans sensitised to penicillin and cephalosporin antibiotics.

Will my dog need to be monitored while on Amoxicillin-clavulanate?

No specific tests are required while your dog is taking Amoxicillin-clavulanate.

Further information

If you have any concerns, further information on Amoxicillin-clavulanate can be found on the package insert and the following websites:

Europe & UK

US

Always follow the recommended dosage and contact your veterinary team or pharmacist if you have any questions regarding your dog’s medication.

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