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CONTRIBUTOR(S): Vetstream Ltd, Gigi Davidson,

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Medication: Lotilaner

Medication: Lotilaner

Your cat has been prescribed the active ingredient lotilaner to treat and control flea and tick infestations.

Key points:
• Ectoparasiticide.
• Must be given with food.
• Wash hands after handling the tablets.
• Do not give to kittens less than 8 weeks of age or cats weighing less than 0.5 kg (1.1 lbs) (Europe & UK) or 0.9 kg (2 lbs) (USA).
• Use with caution in cats with a history of seizures.
• Dosage: every 30 days.

This information sheet is designed to help answer commonly asked questions and help you give the medication safely and effectively to your pet. It does not contain all available information for this medication. If you have other questions or need more information, contact your veterinarian or pharmacist. Always follow the dosing instructions provided by your veterinarian. 

Name, Brand names, Class of medication and Storage

Name
  • Lotilaner (loe-tih-LAN-er).
Brand name
  • Credelio®.
Class of medication
  • Ectoparasiticide.
  • Insecticide and acaricide belonging to the isoxazoline family.
Storage
  • Chewable tablets should be stored at 15°C-25°C (59°F-77°F).
  • Shelf life: 2 years.

Why has my cat been prescribed lotilaner?

Your veterinarian has prescribed lotilaner for the treatment of the following fleas and ticks:

Europe & UK

  • Fleas (Ctenocephalides felis) infestation in cats and kittens 8 weeks of age and older and weighing more than 0.5 kg (1.1 lbs) for 1 month.
  • Ticks (Ixodes ricinus) in kittens and cats weighing more than 0.5 kg (1.1 lbs) for 1 month (no efficacy data against ticks in cats aged less than 5 months).

USA

  • Fleas (Ctenocephalides felis) in cats and kittens 8 weeks of age and older and weighing more than 0.9 kg (2 lbs) for 1 month.
  • Ticks (Ixodes scapularis) in kittens 6 months and older and weighing more than 0.9 kg (2 lbs) for 1 month.

Lotilaner can be used as part of a treatment strategy for control of flea allergy dermatitis (FAD).

How is the medication given?

Lotilaner is given orally. The vanilla-yeast flavored chewable tablets should be given with a meal or within 30 minutes after feeding.

There are two sizes of tablets available to be administered to cats and kittens according to their weight. Make sure your cat consumes the complete dose. If you suspect that part of the dose has been lost or if vomiting occurs within 2 hours of administration, re-dose with another full dose.

Are there any side-effects or drug interactions?

The following side-effects have been reported: weight loss, elevated blood urea nitrogen, increased urination, and diarrhea.

Lotilaner is an isoxazoline and potential side-effects of this class of drug are neurologic adverse reactions including tremors, incoordination, and seizures. Therefore, lotilaner should be used with caution in cats with a history of seizures or neurologic disorders.

There are no known interactions of lotilaner with other drugs.

How long will my cat need to receive this medication?

Lotilaner is given at monthly intervals throughout the flea and/or tick seasons. Your veterinarian may recommend a different schedule based on local or regional circumstances and risk factors.

How should I dispose of this medication if I don’t use it all?

Dispose of any unused lotilaner safely – don’t flush down the toilet or sink. Ask your veterinary team if they take back medication for disposal. Do not save lotilaner for future use or give to other pets.

What if I miss a dose or give an extra dose?

If it is suspected that any of the dose has been lost or if vomiting occurs within 2 hours of administration, re-dose with another full dose. If you miss a dose, give the dose as soon as possible but do not double up a dose. Make sure the dose given doesn’t exceed the total recommended amount in any 24-hour period. However, no adverse reactions were observed following oral administration to kittens 8 weeks of age at 3 and 5 times the label dose every 28 days for 8 doses.

My cat is unwell, should I still give the drug?

If your pet is unwell, contact your veterinarian for advice.

What should I do if this medication is accidentally given to another pet or taken by a human?

Lotilaner should only be given to the cat that it has been prescribed for:

  • Do not give to other pets in the household
  • Do not give to kittens less than 8 weeks of age or cats weighing less than 0.5 kg (1.1 lbs) (Europe & UK) or 0.9 kg (2 lbs) (USA)
  • Use with caution in cats with a history of seizures
  • Safety in breeding, pregnant or lactating cats has not been established
  • If accidentally given to other pets, contact your veterinarian for advice.

If accidentally eaten by a human, speak to your primary care physician or poison control center.

Will my cat need to be monitored while on lotilaner?

No specific tests are required while your cat is taking lotilaner.

Further information

If you have any concerns, further information on lotilaner can be found on the package insert and the following websites:

Europe & UK

USA

Always follow the recommended dosage and contact your veterinary team or pharmacist if you have any questions regarding your cat’s medication.

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